I-Resmetirom

Igama leMchiza:

I-Resmetirom

Ikhowudi yoncumo:

N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O

Ikhowudi ye-InChi:

InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11( 14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27, 28)

Isitshixo se-InChi:

FDBYIYFVSAHJLY-UHFFFAOYSA-N

Igama elingundoqo:

MGL-3196; MGL 3196; VIA 3196; I-VIA-3196; I-Resmetirom

Ukunyibilika:Inyibilika kwi-DMSO, hayi emanzini

Ugcino:0 - 4 C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20 C ixesha elide (iinyanga)

Inkcazo:

I-Resmetirom, eyaziwa ngokuba yi-MGL-3196, inamandla kwaye ikhetha kakhulu i-hormone ye-thyroid receptor β agonist kwiimvavanyo zekliniki zonyango lwe-dyslipidemia. Imiphumo emihle ye-hormone ye-thyroid (TH) kumanqanaba e-lipid ngokuyinhloko ngenxa yesenzo sayo kwi-hormone ye-thyroid receptor β (THR-β) esibindi, ngelixa imiphumo emibi, kubandakanywa nemiphumo yenhliziyo, idibene ne-thyroid hormone receptor α (THR). -α).

Ithagethi: THR-β