I-Quarfloxin

Igama leMchiza:

5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl )-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

Ikhowudi yoncumo:

FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC[ C@H]7N(C)CCC7)=O)C8=O)C8=C1

Ikhowudi ye-InChi:

InChI=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42 -29-15-21-5-2-3-6-22(21)16-30(29)45-34-31(42)25(33(26)43)17-27 (36)32(34)41-14-9-23(19-41)28-18-37-11-12-38-28/h2-3,5-6,11-12 ,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H,39,44)/t23-,24+/m1/s1

Isitshixo se-InChi:

WOQIDNWTQOYDLF-RPWUZVMVSA-N

Igama elingundoqo:

CX 3543; CX-3543; CX 3543; I-Quarfloxacin

Ukunyibilika: 

Ugcino: 

Inkcazo:

I-Quarfloxin, ekwabizwa ngokuba yi-Quarfloxacin kunye ne-CX-3543, iphuma kwi-fluoroquinolone kunye nomsebenzi we-antineoplastic. I-Quarfloxin iphazamisa ukusebenzisana phakathi kweprotheni ye-nucleolin kunye ne-G-quadruplex isakhiwo se-DNA kwi-template ye-ribosomal DNA (rDNA), intsebenziswano ebalulekileyo ye-rRNA biogenesis echazwe ngokugqithiseleyo kwiiseli zomhlaza; ukuphazamiseka kwe-G-quadruplex DNA: iprotein intsebenziswano kwi-aberrant rRNA biogenesis inokubangela ukuvinjelwa kwe-ribosome synthesis kunye ne-tumor cell apoptosis.

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