I-NST-628
Iinkcukacha zeMveliso
Iithegi zeMveliso
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Igama leMchiza:
3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(3-fluoropyridin-2-yl)oxy-4-methylchromen-2-enye
Ikhowudi yoncumo:
FC1=C(OC2=CC=C(C(C)=C(CC3=C(F)C(NS(NC)(=O)=O)=NC=C3)C(O4)=O)C4= C2)N=CC=C1
Ikhowudi ye-InChi:
InChI=1S/C22H18F2N4O5S/c1-12-15-6-5-14(32-21-17(23)4-3-8-27-21)11-18(15)33-22(29)16( 12)10-13-7-9-26-20(19(13)24)28-34(30,31)25-2/h3-9,11,25H,10H2,1-2H3,(H,26) , 28)
Isitshixo se-InChi:
YQSZJOABXRROQR-UHFFFAOYSA-N
Igama elingundoqo:
3002056-30-3;CAS:3002056-30-3;CAS:3002056-30-3;NST-628;NST628;NST 628
Ukunyibilika:
Ugcino:Yomile, emnyama kunye ne-0 -4 C kwixesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).
Inkcazo:
I-NST-628 yindlela ye-MAPK ye-molecular gel ene-blood-brain barrier permeability, enokuthintela i-RAF phosphorylation kunye nokusebenza kwe-MEK.
Ithagethi: iRAF phosphorylation kunye ne-MEK