LOXO-305;LY 3527727;Pirtobrutinib

Igama leMchiza:

(S) -5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4- carboxamide

Ikhowudi yoncumo:

O=C(C1=C(N)N([C@@H](C)C(F)(F)F)N=C1C2=CC=C(CNC(C3=CC(F)=CC=C3OC )=O)C=C2)N

Ikhowudi ye-InChi:

InChI=1S/C22H21F4N5O3/c1-11(22(24,25)26)31-19(27)17(20(28)32)18(30-31)13-5-3-12(4-6- 13)10 -29-21(33)15-9-14(23)7-8-16(15)34-2/h3-9,11H,10,27H2,1-2H3,(H2,28,32)(H ,29,33)/t11-/m0/s1

Isitshixo se-InChi:

FWZAWAUZXYCBKZ-NSHDSACASA-N

Igama elingundoqo:

2101700-15-4;CAS:2101700-15-4;CAS:2101700-15-4;LOXO-305;LOXO 305;LOXO305;LY 3527727;LY-3527727;LY3527727b;

Ukunyibilika: 

Ugcino:Yomile, emnyama kunye ne-0 - 4 C kwixesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).

Inkcazo:

I-Pirtobrutinib (i-LOXO-305) yinto ekhethiweyo kakhulu kunye ne-non-covalent yesizukulwana esilandelayo se-BTK inhibitor enokuthintela ukuguqulwa kweenguqu ezahlukeneyo ze-BTK C481.

Ithagethi: BTK