I-ingliforib

Igama leMchiza:

5-chloro-N-((2S,3R)-4-((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)- 1H-indole-2-carboxamide

Ikhowudi yoncumo:

O[C@H](C1)[C@@H](O)CN1C([C@H](O)[C@H](CC2=CC=CC=C2)NC(C3=CC4=C( N3)C=CC(Cl)=C4)=O)=O

Ikhowudi ye-InChi:

InChI=1S/C23H24ClN3O5/c24-15-6-7-16-14(9-15)10-18(25-16)22(31)26-17(8-13-4-2-1-3- 5-13)21(30)23(32)27-11-19(28)20(29)12-27/h1-7,9-10,17,19-21,25,28-30H,8, 11-12H2,(H,26,31)/t17-,19-,20+,21+/m0/s1

Isitshixo se-InChi:

GVDRZOORHCTAN-MJUUVYJYSA-N

Igama elingundoqo:

i-ingliforib; I-CP-296; I-CP-368; I-CP-368,296; CP296; I-CP 296; I-CP-368296; CP368296; CP 368296

Ukunyibilika:I-DMSO

Ugcino: 

Inkcazo:

I-Ingliforib, eyaziwa ngokuba yi-CP-368296, yinoveli ye-glycogen phosphorylase inhibitor. I-Ingliforib ineempawu ze-antihyperglycemic kunye ne-cardioprotective. I-Ingliforib inqanda i-glycogen phosphorylase, i-enzyme yokunciphisa izinga kwi-glycogenolysis, ngaloo ndlela ikhusela ukukhululwa kwe-glucose-1 phosphate kwi-molecule ye-glycogen esibindi. Le arhente iphinda inqanda i-glycogen phosphorylase kwimisipha yentliziyo kwaye inokukhusela intliziyo kwingozi ye-myocardial ischemic ngokugcina umxholo we-glycogen kunye nokuphucula ukudibanisa kwe-glycolytic-oxidative.

Ithagethi: glycogen phosphorylase