GDC6036;GDC6036 iiatropisomers

Igama leMchiza:

I-2-Propen-1-enye, 1-[(3S)-4-[7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2- [[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-

Ikhowudi yoncumo:

C=CC(N1C[C@H](C)N(C2=C3C=C(Cl)C(C4=NC(N)=CC(C)=C4C(F)(F)F)=C(F )C3=NC(OC[C@H]5N(C)CCC5)=N2)CC1)=O

Ikhowudi ye-InChi:

InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32,) 33)34)15(2)11-20(35)36-26)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17) 4/h5,11-12,16-17H,1,6-10,13-14H2,2-4H3,(H2,35,36)/t16-,17-/m0/s1

Isitshixo se-InChi:

ZRBPIAWWRPFDPY-IRXDYDNUSA-N

Igama elingundoqo:

2417917-17-8;CAS:2417917-17-8;CAS:2417917-17-8;GDC6036 atropisomers; I-GDC-6036; I-GDC 6036; GDC6036

Ukunyibilika: 

Ugcino:Yomile, emnyama kunye ne-0 - 4 C kwixesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).

Inkcazo:

I-isomer ye-GDC6036 echasene nokujikeleza iqulethe iindidi ezimbini ze-GDC6036 i-isomer yokujikeleza. I-GDC-6036, Ikwaziwa ngokuba yi-RG6330, ifumaneka ngomlomo, iyasebenza kakhulu, kwaye ikhetha i-KRAS G12C inhibitor.

Ithagethi: KRAS G12C