Etoricoxib

Igama leMchiza:

5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl] -2,3'-bipyridine

Ikhowudi yoncumo:

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

Ikhowudi ye-InChi:

InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6- 13)24(2,22)23/h3-11H,1-2H3

Isitshixo se-InChi:

MNJVRJDLRVPLFE-UHFFFAOYSA-N

Igama elingundoqo:

Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663, 202409-33-4

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)

Inkcazo:

I-Etoricoxib yinto yokwenziwa, i-nonsteroidal anti-inflammatory drug (NSAID) kunye ne-antipyretic, i-analgesic, kunye neempawu ezinokuthi zibe ne-antineoplastic. I-Etoricoxib ibophelela ngokukodwa kwaye inqanda i-enzyme cyclooxygenase-2 (COX-2), okubangela ukuthintela ukuguqulwa kwe-arachidonic acid kwi-prostaglandins. Ukuvinjelwa kwe-COX-2 kunokubangela i-apoptosis kwaye kuthintele ukwanda kweeseli ze-tumor kunye ne-angiogenesis.

Ithagethi: COX-2