Divarasib,GDC 6036

Igama:1-((S)-4-(7-((R)-6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((( S)-1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)prop-2-en-1-one

Inombolo yekhathalogu:CPD112857

Inombolo yeCAS:2417987-45-0

Ubunzima beMolekyuli:622.06

Ifomula yemichiza:C29 H32 Cl F4 N7 O2

Kuphando lwenzululwazi kuphela, hayi izigulane.

Thumela i-imeyile kuthi Khuphela njengePDF

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ubungakanani bePakethe	Ubukho	Ixabiso (USD)
0.1G	Ikhona evenkileni	550
0.5G	Ikhona evenkileni	860
1G	Ikhona evenkileni	1250

Igama leMchiza:

1-((S)-4-(7-((R)-6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((( S)-1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)prop-2-en-1-one

Ikhowudi yoncumo:

NC1=N[C@]([C@]2=C(C=C3C(N=C(N=C3N4[C@H](CN(CC4)C(C=C)=O)C)OC[ C@H]5N(CCC5)C)=C2F)Cl)=C(C(C)=C1)C(F)(F)F

Ikhowudi ye-InChi:

InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32,) 33)34)15(2)11-20 (35)36-26)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17)4/h5,11-12,16-17H ,1,6-10,13-14H2,2-4H3,(H2,35,36)

Isitshixo se-InChi:

ZRBPIAWWRPFDPY-UHFFFAOYSA-N

Igama elingundoqo:

2417987-45-0;CAS:2417987-45-0;CAS:2417987-45-0;Divarasib;GDC 6036

Ukunyibilika:I-SolubilityKuya kuqinisekiswa

Ugcino:Yomile, emnyama kunye ne-0 - 4 C kwixesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).

Inkcazo:

I-Divarasib (GDC-6036) yi-KRAS G12C inhibitor ene-bioavailability yomlomo kunye nokukhetha.

Ithagethi: KRAS G12C inhibitor

Ngaphambili: Asundexian, BI1265162

Okulandelayo: I-4,6-dichloro-5-fluoro-2-(methylsulfanyl) pyrimidine