BMS-986195
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 300 |
| 500mg | Ikhona evenkileni | 850 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(S)-4-(3-(kodwa-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
Ikhowudi yoncumo:
FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1
Ikhowudi ye-InChi:
InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18- 17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13 -/m0/s1
Isitshixo se-InChi:
VJPPLCNBDZIFG-ZDUSSCGKSA-N
Igama elingundoqo:
BMS-986195, BMS 986195, BMS986195, 1912445-55-6
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-BMS-986195 inamandla, i-covalent, inhibitor engenakuguqulwa ye-Bruton's tyrosine kinase (BTK), ilungu lentsapho ye-Tec ye-non-receptor tyrosine kinases ebalulekileyo kwi-antigen-exhomekeke kwi-B-cell signaling kunye nomsebenzi. I-BMS-986195 ingaphezulu kwe-5000-fold selective for BTK phezu kwazo zonke i-kinases ngaphandle kwe-Tec family, kunye ne-selectivity ranges ukusuka kwi-9 ukuya kwi-1010-fold ngaphakathi kwentsapho ye-Tec. I-BMS-986195 i-BTK engasebenziyo kwigazi elipheleleyo lomntu kunye nesantya esikhawulezayo sokungasebenzi (3.5 × 10-4 nM-1 · min-1) kunye ne-potently inhibited antigen-dependent interleukin-6 production, CD86 expression and proliferation in B cells (IC50)<1 nM) ngaphandle kwempembelelo kwimilinganiselo ye-antigen-ezimeleyo kwiiseli ezifanayo.
Ithagethi: BTK
