ARS-1323-Alkyne

Igama leMchiza:

3-((4-(4-acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-2-yl)amino)-N-methyl-N- (prop-2-yn-1-yl)propanamide

Ikhowudi yoncumo:

O=C(N(C)CC#C)CCNC1=NC(N2CCN(C(C=C)=O)CC2)=C3C=C(Cl)C(C4=C(O)C=CC=C4F) =C(F)C3=N1

Ikhowudi ye-InChi:

InChI=1S/C28H27ClF2N6O3/c1-4-11-35(3)22(40)9-10-32-28-33-26-17(27(34-28)37-14-12-36(13- 15-37) 21(39)5-2)16-18(29)23(25(26)31)24-19(30)7-6-8-20(24)38/h1,5-8,16,38H, 2,9-15H2,3H3,(H,32,33,34)

Isitshixo se-InChi:

FCCFZQSNDSLLMI-UHFFFAOYSA-N

Igama elingundoqo:

2436544-27-1;CAS:2436544-27-1;CAS:2436544-27-1;ARS-1323-Alkyne; I-ARS1323-Alkyne; I-ARS 1323-Alkyne; ARS-1323 Alkyne

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:Yomile, emnyama kunye ne-0 - 4 C kwixesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).

Inkcazo:

I-ARS-1323-alkyne, i-switch-II pocket (S-IIP) inhibitor

Ithagethi: tshintsha-II ipokotho (S-IIP)