SJ-01
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
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Lebitso la lik'hemik'hale:
(E) -1-(3-(3,4,5-trimethoxyphenyl)acryloyl) -5,6-dihydropyridin-2(1H)-one
SMILES Khouto:
O=C1C=CCCN1C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O
Khoutu ea InChi:
InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6- 15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
InChi Key:
VABYUUZNAVQNPG-BQYQJAHWSA-N
Keyword:
20069-09-4;CAS:20069-09-4;CAS:20069-09-4;Piperlongumine; Piplatine.
Sollubility:E qhibiliha ka DMSO
Polokelo:E omme, e lefifi le ho 0 - 4 C bakeng sa nako e khutšoanyane (matsatsi ho isa ho libeke) kapa -20 C bakeng sa nako e telele (likhoeli ho isa ho lilemo).
Tlhaloso:
Piperlongumine, eo hape e tsejoang e le Piplatine, ke alkaloid/amide e sebetsang ka biologically ho tloha pelepele, joalo ka pepere e telele (Piper longum L. - Piperaceae). Pepere e telele ke e 'ngoe ea tse sebelisoang haholo meriana ea Ayurvedic, e sebelisetsoang ho phekola maloetse a mangata, ho akarelletsa le lihlahala. Mesebetsi e tlalehiloeng ea pharmacological ea piplatine e kenyelletsa cytotoxic, genotoxic, antitumor, antiangiogenic, antimetastatic, antiplatelet aggregation, antinociceptive, anxiolytic, antidepressant, anti-atherosclerotic, antidiabetic, antibacterial, antifungal, leishmanicidal, trypanocistomidal le schistosomidal activities. Har'a liphello tse ngata tsa meriana ea piplatine, thepa ea eona ea anticancer ke eona e tšepisang ka ho fetisisa.
Sepheo: Piperlongumine ke alkaloid e thibelang phetoho ea myofibroblasts ka ho thibela erk1/2 tsela ea pontšo.