S-600918, Sivopixant

Lebitso la lik'hemik'hale:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl] -2-methylpropanoic acid

SMILES Khouto:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

Khoutu ea InChi:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17) 28-1 9-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)( H,28,29,34)/t16-/m0/s1

InChi Key:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Keyword:

2414285-40-6; CAS:2414285-40-6; CAS: 2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Sollubility:E qhibiliha ka DMSO

Polokelo:E omme, e lefifi le ho 0 - 4 C bakeng sa nako e khutšoanyane (matsatsi ho isa ho libeke) kapa -20 C ka nako e telele (likhoeli ho isa ho lilemo)

Tlhaloso:

Sivopixant, eo hape e tsejoang e le S-600918, ke mohanyetsi ea khethiloeng oa P2X3 (P2X3 IC50, 4.2 nM; P2X2 / 3 IC50, 1100 nM). Sivopixant e bontšitse phello e matla ea analgesic ka mokhoa oa rat partial sciatic nerve ligation model (Seltzer model) ea allodynia (ED50, 0.4 mg / kg).

Sepheo: Mohanyetsi ea khethiloeng oa P2X3