Resmetirom

Lebitso la lik'hemik'hale:

Resmetirom

SMILES Khouto:

N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O

Khoutu ea InChi:

InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11( 14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27, 28)

InChi Key:

FDBYIYFVSAHJLY-UHFFFAOYSA-N

Keyword:

MGL-3196; MGL 3196; VIA 3196; VIA-3196; Resmetirom

Sollubility:E qhibiliha ka DMSO, eseng ka metsing

Polokelo:0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa libeke), kapa -20 C bakeng sa nako e telele (likhoeli)

Tlhaloso:

Resmetirom, eo hape e tsejoang e le MGL-3196, ke receptor e matla le e khethollang haholo ea qoqotho ea qoqotho receptor β agonist litekong tsa meriana bakeng sa phekolo ea dyslipidemia. Liphello tse molemo tsa hormone ea qoqotho (TH) maemong a lipid haholo-holo ka lebaka la ketso ea eona ho thyroid hormone receptor β (THR-β) sebeteng, ha liphello tse mpe, ho kenyelletsa le liphello tsa pelo, li kena lipakeng ke thyroid hormone receptor α (THR). -α).

Sepheo: THR-β