Senyesemane

Lebitso la lik'hemik'hale:

5-chloro-N-((2S,3R)-4-((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)- 1H-indole-2-carboxamide

SMILES Khouto:

O[C@H](C1)[C@@H](O)CN1C([C@H](O)[C@H](CC2=CC=CC=C2)NC(C3=CC4=C( N3)C=CC(Cl)=C4)=O)=O

Khoutu ea InChi:

InChI=1S/C23H24ClN3O5/c24-15-6-7-16-14(9-15)10-18(25-16)22(31)26-17(8-13-4-2-1-3- 5-13)21(30)23(32)27-11-19(28)20(29)12-27/h1-7,9-10,17,19-21,25,28-30H,8, 11-12H2,(H,26,31)/t17-,19-,20+,21+/m0/s1

InChi Key:

GVDRZOORHCTAN-MJUUVYJYSA-N

Keyword:

Ingliforib; CP-296; CP-368; CP-368,296; CP296; CP 296; CP-368296; CP368296; CP 368296

Sollubility:DMSO

Polokelo: 

Tlhaloso:

Ingliforib, eo hape e tsejoang e le CP-368296, ke buka ea glycogen phosphorylase inhibitor. Ingliforib e na le thepa ea antihyperglycemic le cardioprotective. Ingliforib e thibela glycogen phosphorylase, enzyme e fokotsang sekhahla ho glycogenolysis, ka hona e thibela ho lokolloa ha glucose-1 phosphate molek'hule ea glycogen sebeteng. Setsi sena se boetse se thibela glycogen phosphorylase mesifa ea pelo 'me e ka sireletsa pelo ho tsoa kotsi ea myocardial ischemic ka ho boloka litaba tsa glycogen le ho ntlafatsa ho kopana ha glycolytic-oxidative.

Sepheo: glycogen phosphorylase