BI-2852

Lebitso la lik'hemik'hale:

(S) -5-hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl) -1H-indol-3-yl)isoindolin-1-one

SMILES Khouto:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

Khoutu ea InChi:

InChI=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29(24-4-2-3-5-26(2 4)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2-13,16,18,30,32,34,38H,14- 15,17H2,1H3,(H,35,39)/t30-/m0/s1

InChi Key:

JYEQLXOWWLNVDX-PMERELPUSA-N

Keyword:

Sollubility: 

Polokelo: 

Tlhaloso:

BI-2852 ke inhibitor e matla ea KRAS e kopanyang le nanomolar affinity ka pokothong, ho fihlela joale ho nahanoa hore "ha e na thuso," lipakeng tsa switch I le II ho RAS. BI-2852 e fapane ka mokhoa o ikhethileng ho li-inhibitors tsa KRASG12C tse sebetsang hobane e tlama pokothong e fapaneng e teng mefuteng e sebetsang le e sa sebetseng ea KRAS. BI-2852 e thibela GEF, GAP, le tšebelisano e sebetsang le KRAS, e lebisang ho thibelo ea pontšo e tlaase le phello ea antiproliferative liseleng tsa KRAS tse feto-fetohang.

Sepheo: KRAS