Sitagliptin
Faahfaahinta Alaabta
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Magaca Kiimikada:
Sitagliptin (INN; oo hore loogu aqoonsaday MK-0431 oo lagu iibiyay magaca ganacsiga Januvia) waa antihyperglycemic afka ah (daawoyinka ka hortagga sokorowga) ee fasalka inhibitor dipeptidyl peptidase-4 (DPP-4).
Koodhka dhoola cadeynta:
O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O (O) O.[H] O[H]
Koodhka InChi:
InChi=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27- 13 (7-26)24-25-15 (27)16 (20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;( H3,1,2,3,4);1H2/t9-;/m1../s1
Furaha InChi:
GQPYTJVDPQTBQC-KLQYNRQASA-N
Ereyga muhiimka ah:
Sitagliptin, Sitagliptin phosphate, Januvia, Glactiv, ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6
Xalka:Ku milmay DMSO
Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).
Sharaxaad:
Sitagliptin (INN; oo hore loogu aqoonsaday MK-0431 oo lagu iibiyay magaca ganacsiga Januvia) waa antihyperglycemic afka ah (daawoyinka ka hortagga sokorowga) ee fasalka inhibitor dipeptidyl peptidase-4 (DPP-4). Waxaa soo saaray oo suuq geeyey shirkadda Merck & Co. Daawadan xannibaysa enzyme-ka waxa loo isticmaalaa kaligiis ama lagu daro walxaha kale ee ka hortagga hyperglycemic ee afka ah (sida metformin ama thiazolidinedione) si loogu daweeyo cudurka macaanka ee nooca 2. Faa'iidada daawadan waa waxyeelooyinkeeda hoose (tusaale, hypoglycemia yar, korodhka miisaanka oo yaraada) ee xakamaynta qiyamka gulukooska dhiigga. Exenatide (Byetta) waxay sidoo kale ku shaqeysaa saameynteeda nidaamka incretin.
Ujeedka: DPP-4