SB-204990

Magaca Kiimikada:

trans-5-[6- (2,4-Dichlorophenyl) hexyl] tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

Koodhka dhoola cadeynta:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Koodhka InChi:

InChi=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,1) 1-16 (21)22)17 (23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

Furaha InChi:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Ereyga muhiimka ah:

SB-204990, SB 204990, SB204990

Xalka: 

Kaydinta: 

Sharaxaad:

SB-204990 waa soosaarayaasha awoodda leh ee ATP citrate-lyase inhibitor SB-201076. SB-204990, marka afka laga qaato jiirka, ayaa lagu nuugay wareegga nidaamka, fiirsashada dawooyinka ee SB-201076 ayaa laga soo kabsaday beerka. SB-204990 (25 mg/kg maalintii) ayaa sidoo kale hoos u dhigtay heerarka kolestaroolka plasma (ilaa 23%) iyo heerarka triglyceride (ilaa 38%) ee eyga, oo doorbidaya hoos u dhigista lipoprotein hoose marka la barbar dhigo kolestaroolka sare ee lipoprotein heerarka. SB-204990 waa enzym muhiim ah oo lagu xakameynayo sahayda substrate ee isku dhafka lipid de novo iyo bartilmaameedka suurtagalka ah ee enzyme ee faragelinta hypolipidaemic.

Bartilmaameedka: