| CPD3611 | SB-204990 | SB-204990 waa soosaarayaasha awoodda leh ee ATP citrate-lyase inhibitor SB-201076. SB-204990, marka afka laga qaato jiirka, ayaa lagu nuugay wareegga nidaamka, fiirsashada dawooyinka ee SB-201076 ayaa laga soo kabsaday beerka. SB-204990 (25 mg/kg maalintii) ayaa sidoo kale hoos u dhigtay heerarka kolestaroolka plasma (ilaa 23%) iyo heerarka triglyceride (ilaa 38%) ee eyga, oo doorbidaya hoos u dhigista lipoprotein hoose marka la barbar dhigo kolestaroolka sare ee lipoprotein heerarka. SB-204990 waa enzym muhiim ah oo lagu xakameynayo sahayda substrate ee isku dhafka lipid de novo iyo bartilmaameedka suurtagalka ah ee enzyme ee faragelinta hypolipidaemic. |
