IACS-010759

Magaca Kiimikada:

5- (5-methyl-1- (3- (4- (methylsulfonyl))piperidin-1-yl) benzyl) -1H-1,2,4-triazol-3-yl) -3- (4- (trifluoromethoxy) phenyl)-1,2,4-oxadiazole

Koodhka dhoola cadeynta:

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C)=O)CC5 N3)=N2)C=C1

Koodhka InChi:

InChi=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34 (16)15-17-4-3-5-19 (14-17)33-12-10-21 (11-13-33)39(2,35)36/h3-9,14, 21H,10-13,15H2,1-2H3

Furaha InChi:

HWJWNWZJUYCGKV-UHFFFAOYSA-N

Ereyga muhiimka ah:

IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

IACS-010759 ama IACS-10759 waa mid awood leh oo doorta Oxidative Phosphorylation Inhibitor (IC50)<10 nM) oo leh firfircoonida antineoplastic ee suurtogalka ah. IACS-010759 waxay ku xidhaa oo ay joojisaa kakanaanta I ee silsiladda gaadiidka elektaroonigga ah (NADH ubiquinone oxidoreductase), si ay u xushaan unugyada burooyinka ee nafaqooyinka, iyo tamarta, iyo joojinta nucleotide iyo wax soo saarka amino acid, taas oo keenta autophagy, sababa dhimashada unugyada burooyinka iyo in la xakameeyo unugyada fidinta. Isku-dhafka Mitochondrial I, kaas oo si xoog leh uga shaqeeya unugyada kansarka si ay u daboolaan baahidooda korodhka ah ee tamarta, ayaa door muhiim ah ka ciyaara kor u qaadida kororka unugyada kansarka.

Ujeedka: OXPHOS