GDC-0326

Magaca Kiimikada:

(S)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d] [1,4] ] oxazepin-9-yl) oxy) propanamide

Koodhka dhoola cadeynta:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

Koodhka InChi:

InChi=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3) )17(20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/ m0/s1

Furaha InChi:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Ereyga muhiimka ah:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)

Sharaxaad:

GDC-0326 waa horjooge awood leh oo xulashada α-Isoform of Phosphoinotide 3-Kinase (PI3Kalpha inhibitor). GDC-0326 waxay ku guulaysataa doorasho heer sare ah oo ka badan kinases kale. GDC-0326 waxay leedahay balaasmaha CL hooseeya ee aadanaha. Qoyska PI3 kinase dhexdiisa, waxa jira afar qaybood oo I PI3K ah (α, β, δ, iyo γ). Kalasoocida kuwan ka mid ah, PI3KA waa tan ugu badan ee lala xiriiriyo kansarka.

Hadafka: PI3K