AZD-5069
Faahfaahinta Alaabta
Tags Product
| Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
| 100mg | In Stock | 500 |
| 500mg | In Stock | 800 |
| 1g | In Stock | 1200 |
| Cabiro badan | Hel Xigasho | Hel Xigasho |
Magaca Kiimikada:
N-(2-(2,3-difluorobenzyl)thio)-6-((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)zetidine-1-sulfonamide
Koodhka dhoola cadeynta:
O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
Koodhka InChi:
InChi=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2, 1H3, (H,21,22,23)/t11-,14+/m1/s1
Furaha InChi:
QZECRCLSIGFCIO-RISCZKNCSA-N
Ereyga muhiimka ah:
AZD-5069, AZD5069, AZD 5069, 878385-84-3
Xalka:Ku milmay DMSO
Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).
Sharaxaad:
AZD-5069 waa mid awood leh oo door ah CXCR2 antagonist oo leh karti uu ku joojiyo socdaalka neutrophil ee marinnada hawo-mareenka ee bukaannada qaba COPD. AZD-5069 waxaa la tusay in ay joojiso ku xidhka radiolabeled CXCL8 ee aadanaha CXCR2 oo leh pIC50 qiimaha 9.1. Intaa waxaa dheer, AZD5069 waxay joojisay chemotaxis neutrophil, oo leh pA2 oo ku dhow 9.6, iyo muujinta molecule adhesion, oo leh pA2 ee 6.9, iyada oo laga jawaabayo CXCL1. AZD5069 waxay ahayd iska soo horjeeda si tartiib ah loo rogi karo ee CXCR2 oo leh saamaynta wakhtiga iyo heerkulka ka muuqda farmashiistaha iyo kinetics-ka xidhitaanka. AZD-5069 sidoo kale waxay faa'iido u leedahay bukaanka xaaladaha bararka.
Ujeedka: CXCR2