THZ2

Anarana simika:

N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidina-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)fa-2- enoyl]amino]benzamide

Kaody SMILES:

O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN) (C)C)=O)=C5

InChi Code:

InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3- 14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+

InChi Key:

FONRCZUZCHXWBD-VGOFMYFVSA-N

Keyword:

THZ-2, THZ 2, THZ2, 1604810-84-5

Solubility:Mety levona amin'ny DMSO

fitahirizana:0 - 4°C mandritra ny fotoana fohy (andro na herinandro), na -20°C mandritra ny fotoana maharitra (volana).

Famaritana:

THZ2, analoga an'ny THZ1, izay mety hitsaboana ny homamiadan'ny nono Triple-negative (TNBC), dia inhibitor CDK7 mahery sy mifantina izay mandresy ny tsy fandriam-pahalemana an'ny THZ1 in vivo. IC50: CDK7= 13,9 nM; sela TNBC = 10 nM

Tanjona: CDK