PCO 371

Lub npe tshuaj:

1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl))-1,3,8-triazaspiro[4.5]dec-1-en-8-yl Tom ntej: Sulfonyl Ethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione

SMILES Code:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3)N=C(C4=CC=C(OC(F)(F)F)F) )C=C4)N5)C5=O)=O)C(C)=C2)=O

InChi Code:

InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30, 31) 32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)

InChi Key:

LDZJFVOUPUFOHX-UHFFFAOYSA-N

Lo lus tseem ceeb:

PCO371; PCO-371; TIAB SA 371

Solubility: 

Cia: 

Nqe lus piav qhia:

PCO371 yog ib qho muaj zog thiab xaiv PTHR1 agonist rau kev kho mob hypoparathyroidism. Kev tswj qhov ncauj ntawm PCO371 rau cov nas osteopenic provokes ib qho tseem ceeb ntawm cov pob txha tig rov qab nrog kev nce ntawm cov pob txha loj. Hauv cov nas hypocalcemic, PCO371 rov kho cov tshuaj calcium hauv cov ntshav yam tsis muaj calcium ntxiv rau hauv cov zis, thiab muaj zog thiab kav ntev dua li kev txhaj tshuaj PTH.

Hom phiaj: PTHR1