JBJ-04-125-02 R-isomer

Lub npe tshuaj:

(R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2) yl) acetamide

SMILES Code:

O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6

InChi Code:

InChI = 1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19(15-23(20)28()) 35) 38) 18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8,11,14-16,26,31,36H,9- 10,12-13,17H2,(H,32,33,37)/t26-/m1/s1

InChi Key:

VHQVOTINPRYDAO-AREMUKBSSA-N

Lo lus tseem ceeb:

Solubility: 

Cia: 

Nqe lus piav qhia:

JBJ-04-125-02 yog ib qho mutant-xaiv EGFR allosteric inhibitor uas muaj peev xwm tiv thaiv qog noj ntshav. Raws li ib tus neeg sawv cev, nws tuaj yeem cuam tshuam cov cell proliferation thiab EGFRL858R / T790M / C797S signaling hauv vitro thiab hauv vivo. Kev sib xyaw ntawm osimertinib thiab JBJ-04-125-02 ua rau muaj kev nce hauv apoptosis, kev cuam tshuam zoo ntawm kev loj hlob ntawm tes, thiab nce kev ua tau zoo hauv vitro thiab hauv vivo piv nrog ib tus neeg sawv cev ib leeg.

Hom phiaj: EGFR