Flibanserin

Lub npe tshuaj:

1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-ib hydrochloride

SMILES Code:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

InChi Code:

InChI = 1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12) -26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

InChi Key:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Lo lus tseem ceeb:

Flibanserin, 167933-07-5

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

Flibanserin yog ib tug tag nrho agonist ntawm 5-HT1A receptor (Ki = 1 nM) thiab, nrog qis affinity, raws li ib tug antagonist ntawm 5-HT2A receptor (Ki = 49 nM) thiab antagonist los yog tsis muaj zog ib feem agonist ntawm D4 receptor ( Ki = 4–24 nM). Txawm hais tias muaj kev sib raug zoo ntau dua ntawm flibanserin rau 5-HT1A receptor, thiab rau cov laj thawj uas tsis paub, flibanserin tuav 5-HT1A thiab 5-HT2A receptors hauv vivo nrog feem pua ​​​​zoo sib xws. Flibanserin kuj tseem muaj kev sib raug zoo rau 5-HT2B receptor (Ki = 89.3 nM) thiab 5-HT2C receptor (Ki = 88.3 nM), ob qho tib si uas nws coj ua tus antagonist ntawm. Flibanserin nyiam ua kom 5-HT1A receptors nyob rau hauv lub prefrontal cortex, ua qauv qhia cheeb tsam xaiv, thiab tau pom tias yuav ua rau kom dopamine thiab norepinephrine ntau ntau thiab txo cov qib serotonin nyob rau hauv cov nas prefrontal cortex, cov kev txiav txim uas tau txiav txim siab los kho kom haum xeeb ntawm 5-HT1A. receptor[12] Xws li, flibanserin tau piav qhia tias yog norepinephrine-dopamine disinhibitor (NDDI). Flibanserin tau pom zoo nyob rau lub Yim Hli 2015 rau kev kho mob ntawm cov poj niam ua ntej poj niam cev xeeb tub nrog hypoactive deev siab tsis zoo (HSDD).

Hom phiaj: 5 HT