Ertugliflozin

Lub npe tshuaj:

(1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3 , 4-tug

SMILES Code:

"CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(C(O3)(CO4)CO)O)O)O)O)Cl"

InChi Code:

InChI = 1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27) 18(25)19(2 6) 21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+ , 21-,22-/m0/s1 "

InChi Key:

"MCIACXAZCBVDEE-CUUWFGFTSA-N"

Lo lus tseem ceeb:

Ertugliflozin, PF 04971729, MK-8835, 1210344-57-2

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

Ertugliflozin, tseem hu ua PF-04971729, yog ib qho muaj zog thiab xaiv inhibitor ntawm sodium-dependent glucose cotransporter 2 thiab cov neeg sib tw kho mob rau kev kho mob ntawm hom 2 mob ntshav qab zib mellitus. Kev tshawb fawb soj ntsuam tau pom tias Ertugliflozin (1-25 mg / hnub) txhim kho glycemic tswj, lub cev hnyav thiab ntshav siab hauv cov neeg mob T2DM suboptimally tswj ntawm metformin, thiab tau txais txiaj ntsig zoo.

Hom phiaj: SGLT-2