IAB 010759

Lub npe tshuaj:

5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)) phenyl)-1,2,4-oxadiazole

SMILES Code:

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1

InChi Code:

InChI = 1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31 -34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14,21H , 10-13,15H2,1-2H3

InChi Key:

HWJWNWZJUYCGKV-UHFFFAOYSA-N

Lo lus tseem ceeb:

IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

IACS-010759 lossis IACS-10759 yog lub zog thiab xaiv Oxidative Phosphorylation Inhibitor (IC50)<10 nM) uas muaj peev xwm ua haujlwm antineoplastic. IACS-010759 khi rau thiab inhibits complex I ntawm electron thauj saw (NADH ubiquinone oxidoreductase), yog li xaiv depriving qog hlwb ntawm cov as-ham, thiab lub zog, thiab inhibiting nucleotide thiab amino acid ntau lawm, uas induces autophagy, ua rau qog cell tuag thiab inhibits cell. kev loj hlob. Mitochondrial complex I, uas yog hyperactivated nyob rau hauv cov qog nqaij hlav cancer kom ua tau raws li lawv cov kev xav tau ntawm lub zog, ua lub luag haujlwm tseem ceeb hauv kev txhawb nqa cov qog nqaij hlav cancer.

Hom phiaj: OXPHOS