AZD0780;EX-A6975;laroprovstatum; larorovstat

Lub npe tshuaj:

6'-(((1S,3S)-3-(((5-(difluoromethoxy)pyrimidin-2-yl)amino)cyclopentyl)amino)-2H-[1,3'-bipyridin]-2-ib

SMILES Code:

O=C1N(C=CC=C1)C2=CN=C(N[C@@H]3C[C@H](CC3)NC4=NC=C(OC(F)F)C=N4)C= C2

InChi Code:

InChI = 1S/C20H20F2N6O2/c21-19(22)30-16-11-24-20(25-12-16)27-14-5-4-13(9-14)26-17-7-6- 15(10-23-17)28-8-2-1-3-18(28)29/h1-3,6-8,10-14,19H,4-5,9H2,(H,23,26 )(H,24,25,27)/t13-,14-/m0/s1

InChi Key:

NCHUWRLOTSAFFN-KBPBESRZSA-N

Lo lus tseem ceeb:

2455427-91-3; CAS: 2455427-91-3; CAS: 2455427-91-3; AZD0780; AB 0780; AB 0780; EX-A6975; EX-A 6975; EXA 6975; larorovstatum; larorovstat

Solubility: 

Cia:Qhuav, tsaus thiab ntawm 0 -4 C rau lub sijhawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sijhawm ntev (hli mus rau xyoo).

Nqe lus piav qhia:

PCSK9-IN-12 yog ib qho heteroaromatic compound. PCSK9-IN-12 muaj kev sib raug zoo rau PCSK9 nrog tus nqi Kd<200 nM. PCSK9-IN-12 tuaj yeem siv rau kev kawm txog cov roj cholesterol metabolism.

Hom phiaj: PCSK9