Sildenafil Citrate

Sunan Sinadari:

5- (2-ethoxy-5- ((4-methylpiperazin-1-yl) sulfonyl) phenyl) -1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo [4,3-d] pyrimidin- 7-daya 2-hydroxypropane-1,2,3-tricarboxylate

Lambar SMILES:

"CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)CC(C(=O)O C(CC(=O)O)(C(=O)O"

Lambar InChi:

InChi=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-) 18 (16) 32-6-2) 33 (30,31) 28-12-10-26 (3) 11-13-28; 7-3 (8) 1-6 (13,5 (11)12. 2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)( H,9,10)(H,11,12)

InChi Key:

DEIYFTQMQPDXOT-UHFFFAOYSA-N

Mabuɗin kalma:

Sildenafil Citrate; UK 92480-10; UK-92,480-10; Revatio, VIAGRA;

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)

Bayani:

Sildenafil, Citrate wani nau'in citrate ne na Sildenafil. Sildenafil ne mai zaɓin zaɓi na PDE5 (nau'in 5 cGMP phosphodiesterase) wanda ke haifar da hydrolysis na 3',5'-cyclic guanosine monophosphate (cGMP). A matsayin mai hana PDE5, Sildenafil an ruwaito don haɓaka neuro-, synapto- da angiogenesis a cikin nau'ikan bera na bugun jini kuma an bayar da rahoton cewa ya zama vasodilator mai laushi. Sildenafil kuma an nuna shi don hana indomethacin-induced ƙananan ƙwayoyin cuta na hanji ta hanyar NO / cGMP-dogara.

Saukewa: PDE5