S-600918, Sivopicant

Sunan Sinadari:

(2S)-3-[(4E) -3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl) oxy] phenyl} imino)-1 ,3,5-triazinan-1-yl] -2-methylpropanoic acid

Lambar SMILES:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC) = CC=C4)C=C3)=O

Lambar InChi:

InChi=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-19-9-11-20 (12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H ,32,33)(H,28,29,34)/t16-/m0/s1

InChi Key:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Mabuɗin kalma:

2414285-40-6; CAS: 2414285-40-6; CAS: 2414285-40-6; Sivopicant; S-600918; S 600918; S600918

Solubility:Mai narkewa a cikin DMSO

Ajiya:Dry, duhu kuma a 0 - 4 C na gajeren lokaci (kwanaki zuwa makonni) ko -20 C na dogon lokaci (watanni zuwa shekaru)

Bayani:

Sivopixant, wanda kuma aka sani da S-600918, zaɓin P2X3 antagonist mai karɓa ne (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). Sivopixant ya nuna tasirin analgesic mai ƙarfi a cikin ƙirar ɓangarorin ɓangaren sciatic jijiya ligation (samfurin Seltzer) na allodynia (ED50, 0.4 mg / kg).

Manufa: Zaɓaɓɓen P2X3 antagonist mai karɓa