Quarfloxin

Sunan Sinadari:

5-fluoro-N- (2- ((S) -1-methylpyrrolidin-2-yl) ethyl -3-oxo-6- ((R) -3- (pyrazin-2-yl) pyrrolidin-1-yl -3H-benzo [b] pyrido [3,2,1-kl] phenoxazine-2-carboxamide

Lambar SMILES:

FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC) C@H]7N(C)CCC7)=O)C8=O)C8=C1

Lambar InChi:

InChi=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42 -29-15-21-5-2-3-6-22 (21)16-30 (29)45-34-31 (42)25(33(26)43)17-27 (36)32(34)41-14-9-23(19-41)28-18-37-11-12-38-28/h2-3,5-6,11-12 ,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H,39,44)/t23-,24+/m1/s1

InChi Key:

WOQIDNWTQOYDLF-RPWUZVMVSA-N

Mabuɗin kalma:

CX 3543; CX-3543; CX 3543; Quarfloxacin

Solubility: 

Ajiya: 

Bayani:

Quarfloxin, wanda kuma aka sani da Quarfloxacin da CX-3543, wani nau'in fluoroquinolone ne tare da aikin antineoplastic. Quarfloxin ya rushe hulɗar tsakanin furotin nucleolin da tsarin DNA na G-quadruplex a cikin samfurin DNA na ribosomal (rDNA), wani muhimmin hulɗar don rRNA biogenesis wanda ke da yawa a cikin kwayoyin ciwon daji; rushewar wannan G-quadruplex DNA: hulɗar sunadaran a cikin rRNA biogenesis na rashin ƙarfi na iya haifar da hana haɗin ribosome da apoptosis cell tumor.

Manufar: