| CAT # | Sunan samfur | Bayani |
| Saukewa: CPD100608 | ASK1-Inhibitor-10 | ASK1 Inhibitor 10 shine mai hanawa na baka mai hanawa na siginar apoptosis mai daidaita kinase 1 (ASK1). Yana da zaɓi don ASK1 akan ASK2 haka kuma MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, da B-RAF. Yana hana haɓakar streptozotocin a cikin JNK da p38 phosphorylation a cikin ƙwayoyin β na pancreatic na INS-1 a cikin hanyar dogaro da hankali. |
| Saukewa: CPD100607 | K811 | K811 shine takamaiman mai hanawa ASK1 wanda ke tsawaita rayuwa a cikin ƙirar linzamin kwamfuta na amyotrophic lateral sclerosis. K811 da kyau ya hana yaduwar kwayar halitta a cikin layin salula tare da babban maganganun ASK1 kuma a cikin HER2-overexpressing GC Kwayoyin. Jiyya tare da K811 ya rage girman ciwace-ciwacen ciwace-ciwacen daji ta hanyar raguwar alamomin yaduwa. |
| Saukewa: CPD100606 | K812 | K812 shine takamaiman mai hanawa ASK1 wanda aka gano don tsawaita rayuwa a cikin ƙirar linzamin kwamfuta na amyotrophic lateral sclerosis. |
| Saukewa: CPD100605 | Saukewa: MSC-2032964A | MSC 2032964A mai ƙarfi ne kuma mai hanawa ASK1 (IC50 = 93 nM). Yana toshe LPS-induced ASK1 da p38 phosphorylation a cikin al'ada linzamin kwamfuta astrocytes da kuma kashe neuroinflammation a cikin wani linzamin kwamfuta model EAE. MSC 2032964A abu ne mai yiwuwa a baka kuma yana shiga kwakwalwa. |
| Saukewa: CPD100604 | Selonsertib | Selonsertib, wanda kuma aka sani da GS-4997, shine mai hanawa na baka mai hanawa na siginar apoptosis mai sarrafa kinase 1 (ASK1), tare da yuwuwar rigakafin kumburi, antineoplastic da ayyukan anti-fibrotic. GS-4997 yana hari kuma yana ɗaure zuwa yankin kinase na catalytic na ASK1 a cikin hanyar gasa ta ATP, ta haka yana hana phosphorylation da kunnawa. GS-4997 yana hana samar da cytokines mai kumburi, saukar da tsarin bayyana kwayoyin halittar da ke cikin fibrosis, yana hana apoptosis mai yawa kuma yana hana yaduwar salula. |
