| CAT # | Sunan samfur | Bayani |
| Saukewa: CPD100603 | Saukewa: MDK36122 | MDK36122, kuma aka sani da H-PGDS Inhibitor I, mai hana Prostaglandin D Synthase (nau'in hematopoietic). MDK36122 bashi da sunan lamba, kuma yana da CAS#1033836-12-2. An yi amfani da lambobi 5 na ƙarshe don suna don sauƙin sadarwa. MDK36122 yana toshe HPGDS (IC50s = 0.7 da 32 nM a cikin enzymes da ƙididdigar salula, bi da bi) tare da ƙaramin aiki akan enzymes ɗan adam L-PGDS, mPGES, COX-1, COX-2, da 5-LOX. |
| Saukewa: CPD100602 | Tepoxalin | Tepoxalin, wanda kuma aka sani da ORF-20485; RWJ-20485; shine mai hana 5-lipoxygenase mai yuwuwa don maganin asma, osteoarthritis (OA). Tepoxalin yana da aikin inhibitory na vivo a kan COX-1, COX-2, da 5-LOX a cikin karnuka a halin yanzu da aka yarda da shawarar da aka ba da shawarar. Tepoxalin yana haɓaka aikin antioxidant, pyrrolidine dithiocarbamate, a cikin ƙaddamar da ƙwayar cuta necrosis factor alpha-induced apoptosis a cikin ƙwayoyin WEHI 164. |
| Saukewa: CPD100601 | Tenidap | Tenidap, wanda kuma aka sani da CP-66248, mai hanawa COX / 5-LOX ne kuma dan takarar cytokine-modulating anti-inflammatory miyagun ƙwayoyi wanda Pfizer ke ci gaba da haɓakawa a matsayin mai yuwuwar jiyya ga cututtukan cututtukan rheumatoid, amma Pfizer ya dakatar da haɓakawa bayan an ƙi amincewa da tallace-tallace. da FDA a 1996 saboda hanta da koda guba, wanda aka dangana ga metabolites na miyagun ƙwayoyi tare da thiophene. kwayoyin halitta wanda ya haifar da lalacewar oxidative. |
| Saukewa: CPD100600 | Saukewa: PF-4191834 | PF-4191834 wani labari ne, mai ƙarfi da zaɓi wanda ba mai hana redox 5-lipoxygenase mai tasiri a cikin kumburi da zafi. PF-4191834 yana nuna kyakkyawan ƙarfi a cikin enzyme- da ƙididdigar tushen tantanin halitta, da kuma a cikin ƙirar bera na kumburi mai tsanani. Sakamakon bincike na Enzyme yana nuna cewa PF-4191834 shine mai hana 5-LOX mai karfi, tare da IC (50) = 229 +/- 20 nM. Bugu da ƙari kuma, ya nuna kusan 300-ninka zaɓi don 5-LOX akan 12-LOX da 15-LOX kuma ba ya nuna wani aiki ga enzymes cyclooxygenase. Bugu da ƙari, PF-4191834 yana hana 5-LOX a cikin jinin mutum, tare da IC (80) = 370 +/- 20 nM. |
| Saukewa: CPD100599 | MK-886 | MK-886, wanda kuma aka sani da L 663536, mai adawa da leukotriene. Yana iya yin wannan ta hanyar toshe furotin mai kunna 5-lipoxygenase (FLAP), don haka yana hana 5-lipoxygenase (5-LOX), kuma yana iya taimakawa wajen magance atherosclerosis. MK-886 yana hana ayyukan cyclooxygenase-1 kuma yana hana tarin platelet. MK-886 yana haifar da canje-canje a cikin sake zagayowar tantanin halitta kuma yana ƙaruwa apoptosis bayan maganin photodynamic tare da hypericin. MK-886 yana haɓaka haɓakar ƙwayar cuta necrosis factor-alpha-induced bambanci da apoptosis. |
| Saukewa: CPD100598 | L-691816 | L 691816 shine mai hanawa mai ƙarfi na amsawar 5-LO duka a cikin vitro kuma a cikin kewayon samfuran vivo. |
| Saukewa: CPD100597 | CMI-977 | CMI-977, wanda kuma aka sani da LPD-977 da MLN-977, shine mai hanawa mai 5-lipoxygenase mai ƙarfi wanda ke shiga cikin samar da leukotrienes kuma a halin yanzu ana haɓaka shi don maganin cutar asma. CMI-977 ya hana hanyar 5-lipoxygenase (5-LO) hanyar kumburin salula don toshe tsararrun leukotrienes, wanda ke taka muhimmiyar rawa wajen haifar da asma. |
| Saukewa: CPD100596 | Saukewa: CJ-13610 | CJ-13610 shine mai hanawa na baki na 5-lipoxygenase (5-LO). CJ-13610 yana hana biosynthesis na leukotriene B4 kuma yana daidaita maganganun IL-6 mRNA a cikin macrophages. Yana da tasiri a cikin preclinical model na zafi. |
| Saukewa: CPD100595 | BRP-7 | BRP-7 shine mai hana furotin mai kunnawa 5-LO (FLAP). |
