Etoricoxib

Sunan Sinadari:

5-Chloro-6'-methyl-3-[4- (methylsulfonyl) phenyl] -2,3'-bipyridine

Lambar SMILES:

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

Lambar InChi:

InChi=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-) 13)24 (2,22)23/h3-11H,1-2H3

InChi Key:

MNJVRJDLRVPLFE-UHFFFAOYSA-N

Mabuɗin kalma:

Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663, 202409-33-4

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)

Bayani:

Etoricoxib magani ne na roba, wanda ba na steroidal anti-inflammatory (NSAID) tare da maganin antipyretic, analgesic, da yuwuwar abubuwan antineoplastic. Etoricoxib musamman yana ɗaure kuma yana hana enzyme cyclooxygenase-2 (COX-2), wanda ya haifar da hana jujjuyawar arachidonic acid zuwa prostaglandins. Hana COX-2 na iya haifar da apoptosis kuma ya hana ƙwayar ƙwayar ƙwayar cuta da angiogenesis.

Saukewa: COX-2