Quarfloxin
Faahfaahinta Alaabta
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Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
Magaca Kiimikada:
5-fluoro-N- (2-(((S))-1-methylpyrrolidin-2-yl) ethyl)-3-oxo-6-((R) -3- (pyrazin-2-yl) pyrrolidin-1-yl -3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
Koodhka dhoola cadeynta:
FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC) C@H]7N(C)CCC7=O)C8=O)C8=C1
Koodhka InChi:
InChi=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42 -29-15-21-5-2-3-6-22(21)16-30(29)45-34-31(42)25(33(26)43)17-27 (36)32(34)41-14-9-23(19-41)28-18-37-11-12-38-28/h2-3,5-6,11-12 ,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H,39,44)/t23-,24+/m1/s1
Furaha InChi:
WOQIDNWTQOYDLF-RPWUZVMVSA-N
Ereyga muhiimka ah:
CX 3543; CX-3543; CX 3543; Quarfloxacin
Xalka:
Kaydinta:
Sharaxaad:
Quarfloxin, oo sidoo kale loo yaqaan Quarfloxacin iyo CX-3543, waa soosaar fluoroquinolone oo leh waxqabad antineoplastic. Quarfloxin wuxuu carqaladeeyaa isdhexgalka ka dhexeeya borotiinka nucleolin iyo qaab-dhismeedka DNA-da G-quadruplex ee ku jira qaabka DNA-da ribosomal (rDNA), isdhexgalka muhiimka ah ee biogenesis rRNA oo si xad dhaaf ah loogu buufiyo unugyada kansarka; carqaladaynta DNA-da G-quadruplex-ka ah: isdhexgalka borotiinka ee rRNA biogenesis-ka aberrant waxa laga yaabaa inay keento joojinta isku-darka ribosomeka iyo apoptosis unugga buro.
Bartilmaameedka: