| CAT # | Magaca Alaabta | Sharaxaada |
| CPD100608 | ASK1-Inhibitor-10 | ASK1 Inhibitor 10 waa horjoogaha afka laga heli karo ee apoptosis signal-regulating kinase 1 (ASK1). Waxay u dooratay ASK1 oo ka sarreeya ASK2 iyo sidoo kale MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, iyo B-RAF. Waxay joojisaa kororka streptozotocin-ku-kordhinta JNK iyo fosforyaalka p38 ee unugyada β-pancreatic ee INS-1 qaab-ku-tiirsanaan. |
| CPD100607 | K811 | K811 waa ASK1-gaar-horjooge u-dheereeya badbaadada moodeelka jiirka ee amyotrophic lateral sclerosis. K811 waxay si hufan uga hortagtay kororka unugyada ee xariiqyada gacanta ee leh muujinta sare ee ASK1 iyo HER2-unugyada GC-ga oo xad dhaaf ah. Daawaynta K811 waxay hoos u dhigtay xajmiyada burooyinka xenograft iyadoo hoos loo dhigayo calaamadaha fidinta. |
| CPD100606 | K812 | K812 waa ASK1-horjooge u gaar ah oo la helay si uu u sii dheereeyo badbaadada moodeelka jiirka ee amyotrophic lateral sclerosis. |
| CPD100605 | MSC-2032964A | MSC 2032964A waa mid awood leh oo la xushay ASK1 inhibitor (IC50 = 93 nM). Waxay xannibaysaa LPS-sababtoo ah ASK1 iyo fosforyaalka p38 ee jiirka dhaqameed ee astrocytes waxayna xakameysaa xanuunka neerfaha ee moodalka EAE. MSC 2032964A waa mid afka laga heli karo oo maskaxda gasha. |
| CPD100604 | Selonsertib | Selonsertib, oo sidoo kale loo yaqaan GS-4997, waa xannibaadaha afka ee apoptosis signal-regulating kinase 1 (ASK1), oo leh waxqabadyo ka-hortagga bararka, antineoplastic iyo ka-hortagga fibrotic-ka. GS-4997 waxay beegsataa oo ay ku xidhaa domainka catalytic kinase ee ASK1 si tartan ah oo ATP ah, si ay uga hortagto fosforyaalkeeda iyo hawlgelinteeda. GS-4997 waxay ka hortagtaa soo saarista cytokines bararka, waxay hoos u dhigtaa muujinta gen ee ku lug leh fibrosis, waxay xakameysaa apoptosis xad-dhaaf ah waxayna joojisaa kororka unugyada. |
