| CAT # | Magaca Alaabta | Sharaxaada |
| CPD100603 | MDK36122 | MDK36122, oo sidoo kale loo yaqaano H-PGDS Inhibitor I, waa Prostaglandin D Synthase (nooca hematopoietic) Inhibitor. MDK36122 ma laha magac kood, oo wuxuu leeyahay CAS#1033836-12-2. 5-ta nambar ee ugu dambeeyay waxaa loo adeegsaday magac si ay u sahlanaato isgaarsiinta. MDK36122 waxay si xushmad leh u xannibaysaa HPGDS (IC50s = 0.7 iyo 32 nM ee enzymes iyo imtixaannada gacanta, siday u kala horreeyaan) oo leh waxqabad yar oo ka dhan ah enzymes-ka aadanaha ee la xidhiidha L-PGDS, mPGES, COX-1, COX-2, iyo 5-LOX. |
| CPD100602 | Tepoxalin | Tepoxalin, oo sidoo kale loo yaqaan ORF-20485; RWJ-20485; waa 5-lipoxygenase inhibitor oo awood u leh daaweynta neefta, osteoarthritis (OA). Tepoxalin waxay leedahay in vivo firfircoonida inhibitory ka soo horjeeda COX-1, COX-2, iyo 5-LOX ee eeyaha ee hadda la ansixiyay qiyaasta lagu taliyey. Tepoxalin waxay wanaajisaa waxqabadka antioxidant, pyrrolidine dithiocarbamate, oo hoos u dhigaysa buro necrosis factor alfa-induced apoptosis ee unugyada WEHI 164. |
| CPD100601 | Tenidap | Tenidap, oo sidoo kale loo yaqaan CP-66248, waa COX/5-LOX inhibitor iyo cytokine-modulating anti-inflammatory drug musharax kaas oo ay ku jirtay horumarinta Pfizer si ay u noqoto daaweyn suurtagal ah oo loogu talagalay rheumatoid arthritis-ka, laakiin Pfizer ayaa joojisay horumarinta ka dib markii ogolaanshaha suuqgeynta la diiday. by FDA ee 1996 sababtoo ah sunta beerka iyo kelyaha, taas oo loo aaneeyay dheef-shiid kiimikaad ee daawada leh unug thiophene ah oo sababay dhaawaca oksaydhka. |
| CPD100600 | PF-4191834 | PF-4191834 waa sheeko cusub, awood leh oo la xushay 5-lipoxygenase inhibitor aan dib-u-habayn oo waxtar u leh bararka iyo xanuunka. PF-4191834 waxay soo bandhigaysaa awood wanaagsan oo ku jirta enzyme-iyo imtixaannada unugyada ku salaysan, iyo sidoo kale qaabka jiirka ee caabuqa ba'an. Natiijooyinka baaritaanka Enzyme waxay muujinayaan in PF-4191834 ay tahay 5-LOX inhibitor oo awood leh, oo leh IC (50) = 229 +/- 20 nM. Intaa waxaa dheer, waxay muujisay qiyaastii 300-laab xulashada 5-LOX ee 12-LOX iyo 15-LOX mana muujinayso wax dhaqdhaqaaq ah oo ku wajahan enzymes cyclooxygenase. Intaa waxaa dheer, PF-4191834 waxay joojisaa 5-LOX ee unugyada dhiigga ee bini'aadamka, oo leh IC (80) = 370 +/- 20 nM. |
| CPD100599 | MK-886 | MK-886, oo sidoo kale loo yaqaan L 663536, waa antagonist leukotriene. Waxaa laga yaabaa inay tan sameyso iyadoo xannibaysa 5-lipoxygenase activating protein (FLAP), sidaas darteed waxay joojinaysaa 5-lipoxygenase (5-LOX), waxayna kaa caawin kartaa daaweynta atherosclerosis. MK-886 wuxuu joojiyaa dhaqdhaqaaqa cyclooxygenase-1 wuxuuna xakameeyaa isku-darka platelet. MK-886 waxay keentaa isbeddel ku yimaada wareegga unugyada waxayna kordhisaa apoptosis ka dib daawaynta sawir-qaadista ee hypericin. MK-886 waxay wanaajisaa burada necrosis factor-alpha-induced farqiga iyo apoptosis. |
| CPD100598 | L-691816 | L 691816 waa horjooge awood leh falcelinta 5-LO labadaba gudaha vitro iyo noocyada kala duwan ee vivo. |
| CPD100597 | CMI-977 | CMI-977, oo sidoo kale loo yaqaan LPD-977 iyo MLN-977, waa 5-lipoxygenase inhibitor oo awood leh oo farageliya soo saarista leukotrienes waxaana hadda loo soo saaray daaweynta neefta dabadheeraad ah. CMI-977 waxay joojisaa 5-lipoxygenase (5-LO) dariiqa caabuqa unugyada si ay u xannibto jiilka leukotrienes, kaas oo door muhiim ah ka ciyaara kicinta neefta bronki. |
| CPD100596 | CJ-13610 | CJ-13610 waa ka hortag afka ah oo firfircoon ee 5-lipoxygenase (5-LO). CJ-13610 waxay joojisaa biosynthesis ee leukotriene B4 waxayna xakameysaa muujinta IL-6 mRNA ee macrophages. Waxay wax ku ool u tahay moodooyinka hore ee xanuunka. |
| CPD100595 | BRP-7 | BRP-7 waa borotiinka firfircoonida 5-LO (FLAP). |
