BMS-986195

Magaca Kiimikada:

(S)-4-(3-(laakiin-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

Koodhka dhoola cadeynta:

FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1

Koodhka InChi:

InChi=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18 -17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/ t13-/m0/s1

Furaha InChi:

VJPPLCNBDLZIFG-ZDUSSCGKSA-N

Ereyga muhiimka ah:

BMS-986195, BMS 986195, BMS986195, 1912445-55-6

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

BMS-986195 waa awood xoog leh, isku-dhafan, horjooge aan la bedeli karin ee Bruton's tyrosine kinase (BTK), xubin ka tirsan qoyska Tec ee non-receptor tyrosine kinases lagama maarmaan u ah calaamadaha B-unugga ku tiirsan antigen iyo shaqada. BMS-986195 waa in ka badan 5000-laab oo lagu xusho BTK dhammaan kinase ka baxsan qoyska Tec, iyo xulashada u dhaxaysa 9- ilaa 1010-laab qoyska Tec gudahood. BMS-986195 aan firfircoonayn BTK ee dhiiga bini'aadamka oo dhan oo leh xawaare degdeg ah oo firfircooni ah (3.5 × 10-4 nM-1 · min-1) oo si xoog leh u xannibay soosaarka interleukin-ku-tiirsan antigen-6, muujinta CD86 iyo kordhinta unugyada B (IC50)<1 nM) iyada oo aan wax saameyn ah ku yeelan tallaabooyinka madax-bannaan ee antigen-ka ee isla unugyada.

Ujeedka: BTK