BI-2852

Magaca Kiimikada:

(S) -5-hydroxy-3-(2-(((1-(1-methyl-1H-imidazole-4-yl)methyl)) -1H-indol-6-yl) methyl) amino) methyl) -1H-indol-3-yl) isoindolin-1-kow

Koodhka dhoola cadeynta:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

Koodhka InChi:

InChi=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29 (24-4-2-3-5-26 (2 4)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2-13,16,18,30,32,34,38H,14- 15,17H2,1H3,(H,35,39)/t30-/m0/s1

Furaha InChi:

JYEQLXOWWLNVDX-PMERELPUSA-N

Ereyga muhiimka ah:

Xalka: 

Kaydinta: 

Sharaxaad:

BI-2852 waa horjooge awood leh oo KRAS ah kaas oo ku xidha xidhiidhka nanomolar ee jeebka, ilaa hadda loo arko inuu yahay "la dabar go'i karo," inta u dhaxaysa beddelka I iyo II ee RAS. BI-2852 farsamo ahaan way ka duwan tahay koojiyeyaasha KRASG12C sababtoo ah waxay ku xidhan tahay jeeb kale oo ku jira qaababka firfircoon iyo kuwa aan shaqayn ee KRAS labadaba. BI-2852 waxay xannibaysaa GEF, GAP, iyo isdhexgalka saamaynta leh ee KRAS, taasoo horseedaysa joojinta calaamadaha hoose iyo saamaynta lidka ku ah unugyada mutant ee KRAS.

Ujeedka: KRAS