BAZ2-ICR

Magaca Kiimikada:

4- (4- (1-methyl-1H-pyrazol-4-yl) -1- (2- (1-methyl-1H-pyrazol-4-yl) ethyl) -1H-imidazol-5-yl) benzonitrile

Koodhka dhoola cadeynta:

CN(N=C1)C=C1C2=C(C3=CC=C(C#N)C=C3)N(CCC4=CN(C)N=C4)C=N2

Koodhka InChi:

InChi=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24) -26 (2)13-18)20 (27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3

Furaha InChi:

RRZVGDGTWNQAPW-UHFFFAOYSA-N

Ereyga muhiimka ah:

BAZ2-ICR, BAZ2ICR, BAZ2 ICR, 1665195-94-7

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

BAZ2-ICR waa baaritaan kiimiko oo heer sare ah oo loogu talagalay daraasadaha shaqeynta ee BAZ2 bromodomains in vitro iyo in vivo. Bromodomain-ka ka kooban borotiinnada BAZ2A/B waxay door muhiim ah ka ciyaaraan dib-u-qaabaynta chromatin iyo nidaaminta RNA-yada aan codayn. BAZ2-ICR waxay leedahay IC50 (BAZ2A) = 130 nM; IC50 (BAZ2B) = 180 nM; logD = 1.05; milanka 25 mM (D2O) iyo F = 70%.

Ujeedka: BAZ2