STING agonista-4

Anarana simika:

1,1'-(butane-1,4-diyl)bis(2-(1-etil-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazole-5-carboxamide)

Kaody SMILES:

O=C(C1=CC=C2N(CCCCN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=CC(C(N)=O)=CC=C35)C(NC(C6=CC (C)=NN6CC)=O)=NC2=C1)N

InChi Code:

InChI=1S/C34H38N12O4/c1-5-45-27(15-19(3)41-45)31(49)39-33-37-23- 17-21(29(35)47)9-11-25(23)43(33)13-7-8-14-44-26-12-10-22(30(36)4 8)18-24(26)38-34(44)40-32(50)28-16-20(4)42-46(28)6-2/h9-12,15-18 H,5-8,13-14H2,1-4H3,(H2,35,47)(H2,36,48)(H,37,39,49)(H,38,40,50)

InChi Key:

ICZSAXDKFXTSGL-UHFFFAOYSA-N

Keyword:

Solubility: 

fitahirizana: 

Famaritana:

STING agonist-4 dia stimulator ny Interferon Genes (STING) agonista receptor miaraka amin'ny tsy miova inhibition (IC50) ny 20 nM. STING agonist-4 dia fitambarana amidobenzimidazole (ABZI) mifandraika roa mifandraika amin'ny simétria mba hamoronana ABZIs (diABZIs) mifandray miaraka amin'ny fifamatorana tsara amin'ny STING sy ny fiasan'ny sela.

Tanjona: STING