BAZ2-ICR

Anarana simika:

4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl) etil)-1H-imidazol-5-yl)benzonitrile

Kaody SMILES:

CN(N=C1)C=C1C2=C(C3=CC=C(C#N)C=C3)N(CCC4=CN(C)N=C4)C=N2

InChi Code:

InChI=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24-26(2)13-18)20(27) 17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3

InChi Key:

RRZVGDGTWNQAPW-UHFFFAOYSA-N

Keyword:

BAZ2-ICR, BAZ2ICR, BAZ2 ICR, 1665195-94-7

Solubility:Mety levona amin'ny DMSO

fitahirizana:0 - 4°C mandritra ny fotoana fohy (andro na herinandro), na -20°C mandritra ny fotoana maharitra (volana).

Famaritana:

BAZ2-ICR dia fikarohana simika tena tsara ho an'ny fandalinana miasa ny BAZ2 bromodomains in vitro sy in vivo. Ny bromodomain misy proteinina BAZ2A / B dia mitana anjara toerana lehibe amin'ny fanavaozana chromatin sy ny fifehezana ny RNA tsy misy code. BAZ2-ICR dia manana IC50 (BAZ2A) = 130 nM; IC50(BAZ2B) = 180 nM; logD = 1.05; solubility 25 mM (D2O) ary F = 70%.

Tanjona: BAZ2