Zidesamtinib; NWS-520

Lub npe tshuaj:

(6R)-22-ethyl-54-fluoro-42,6-dimethyl-22H, 42 H-7-oxa1(3,5)-pyridina-2(3,4)-pyrazola-4(4,5)- [1,2,3]triazola5(1,2)-benzenacycloheptaphan-16-amine

SMILES Code:

FC1=CC([C@](OC2=C(N=CC3=C2)N)(C)[H])=C(C=C1)C4=NN(N=C4CC5=C3N(N=C5)CC) ) C

InChi Code:

InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9- 17 (16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25) /t12-/m1/s1

InChi Key:

DTWUUAFTYSMNQX-GFCCVEGCSA-N

Lo lus tseem ceeb:

2739829-00-4; CAS: 2739829-00-4; CAS: 2739829-00-4; Zidesamtinib; NVL-520; NVL 520; HWV 520

Solubility: 

Cia:Qhuav, tsaus thiab ntawm 0 - 4 C rau lub sijhawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sijhawm ntev (hli mus rau xyoo).

Nqe lus piav qhia:

Zidesamtinib (NVL-520) yog ib qho zoo, xaiv, hais lus nquag, thiab ntshav-hlwb barrier permeable ROS1 fusion thiab tsis kam hloov pauv inhibitor.

Hom phiaj: ROS1