Lirafugratinib; TSI-4008

Lub npe tshuaj:

N-[4-(4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin- 6-yl)phenyl]-2-methylprop-2-enamide

SMILES Code:

C=C(C)C(NC1=CC=C(C2=C(C3=CC=C(OC4=NC=CC(C)=N4)C(F)=C3)C5=C(N)N= CN = C5N2C)C = C1) = O

InChi Code:

InChI = 1S/C28H24FN7O2/c1-15(2)27(37)35-19-8-5-17(6-9-19)24-22(23-25(30)32-14-33-26( 23)36(24)4)18-7-10-21(20(29)13-18)38-28-31-12-11-16(3)34-28/h5-14H,1H2,2- 4H3 (H, 35, 37) (H2, 30, 32, 33)

InChi Key:

XOQVZSSDIQQUGO-UHFFFAOYSA-N

Lo lus tseem ceeb:

2549174-42-5; CAS: 2549174-42-5; CAS: 2549174-42-5; Lirafugratinib; RLY-4008; RLY 4008; TSI 4008

Solubility: 

Cia:Qhuav, tsaus thiab ntawm 0 - 4 C rau lub sijhawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sijhawm ntev (hli mus rau xyoo).

Nqe lus piav qhia:

Lirafugratinib (RLY-4008) yog ib qho kev hais lus nquag, hloov tsis tau, thiab xaiv FGFR2 inhibitor.

Hom phiaj: FGFR2