TSO 964

Lub npe tshuaj:

(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-ib

SMILES Code:

[H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H])C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC = C4

InChi Code:

InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1

InChi Key:

YHPWOYBWUWSJDW-UQKRIMTDSA-N

Lo lus tseem ceeb:

OTS 964, OTS-964, OTS 964, 1338545-07-5

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

OTS964 yog ib qho inhibitor ntawm lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM). Nws tshwj xeeb thaiv cytokinesis, ua rau apoptosis, nyob rau hauv ntau yam ntawm cov qog nqaij hlav cancer. OTS964 induces apoptosis ntawm tib neeg lub ntsws cancer hlwb hauv nas xenografts.

Hom phiaj: TOPK