TSI-0326

Lub npe tshuaj:

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4] oxazepin-9-yl)oxy) propanamide

SMILES Code:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

InChi Code:

InChI = 1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3)17( 20) 26) 4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1

InChi Key:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Lo lus tseem ceeb:

Qauv: GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

GDC-0326 yog ib qho muaj zog thiab xaiv inhibitor ntawm α-Isoform ntawm Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). GDC-0326 ua tiav qib siab ntawm kev xaiv ntau dua lwm cov kinases. GDC-0326 muaj plasma CL tsawg hauv tib neeg. Hauv tsev neeg PI3 kinase, muaj plaub chav kawm I PI3K isoforms (α, β, δ, thiab γ). Ntawm cov isoforms, PI3Kα yog qhov feem ntau cuam tshuam nrog cov qog nqaij hlav.

Hom phiaj: PI3K