LOXO-305; LY 3527727; Pirtobrutinib

Lub npe tshuaj:

(S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4- carboxamide

SMILES Code:

O=C(C1=C(N)N([C@@H](C)C(F)(F)F)N=C1C2=CC=C(CNC(C3=CC(F))=CC=C3OC )=O)C=C2)N

InChi Code:

InChI = 1S/C22H21F4N5O3/c1-11(22(24,25)26)31-19(27)17(20(28)32)18(30-31)13-5-3-12(4-6- 13) 10-29-21(33)15-9-14(23)7-8-16(15)34-2/h3-9,11H,10,27H2,1-2H3,(H2,28,32 )(H,29,33)/t11-/m0/s1

InChi Key:

FWZAWAUZXYCBKZ-NSHDSACASA-N

Lo lus tseem ceeb:

2101700-15-4; CAS: 2101700-15; CAS: 2101700-15; LOXO 305; LONE 5527727; PERTOBRUTINIB

Solubility: 

Cia:Qhuav, tsaus thiab ntawm 0 - 4 C rau lub sijhawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sijhawm ntev (hli mus rau xyoo).

Nqe lus piav qhia:

Pirtobrutinib (LOXO-305) yog ib qho kev xaiv zoo heev thiab tsis yog covalent tiam tom ntej BTK inhibitor uas tuaj yeem cuam tshuam ntau yam kev hloov pauv BTK C481.

Hom phiaj: BTK