PEB-850

Lub npe tshuaj:

N-((R)-1-((((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5 -((((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

SMILES Code:

ClC(C(C(N[C@H](CC1=CC=C(C#N)C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

InChi Code:

InChI = 1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35( 39) 20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-40)9-7-26)22-43-30-14-12- 29(41)13-15-30/h4-11,16-17,19-20,25,29-31,42-43H, 12-15,18,22-23,41H2,1-3H3,(H ,44,45)/t25-,29-,30+,31-/m1/s1

InChi Key:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Lo lus tseem ceeb:

BAY-850; PEB 850; PAB 850

Solubility:DMSO

Cia: 

Nqe lus piav qhia:

"BAY-850 yog ib qho tshuaj ntsuam xyuas rau ATAD2A bromodomain uas hloov acetylated H4 peptide los ntawm ATAD2 bromodomain nrog IC50 tus nqi ntawm 20 nM (HTRF). 850 qhia txog kev xaiv zoo tshaj plaws rau tag nrho lwm cov bromodomains (tsis muaj hits hauv BROMOscan ntawm 10 µM) thiab tshem tawm tag nrho-ntev ATAD2 los ntawm chromatin hauv cov hlwb nyob ntawm qhov concentration ntawm 1 µM raws li kev txiav txim siab los ntawm FRAP Kom tsis txhob muaj peev xwm ua tsis tau raws li qhov tshwm sim ntawm ≥ 5 µM tsis pom zoo (http://www.thesgc.org/chemical-probes/BAY-850) "

Lub Hom Phiaj: Tshuaj ntsuam xyuas rau ATAD2A bromodomain