S-600918, Sivopixant

Lub npe tshuaj:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 3,5-triazinan-1-yl]-2-methylpropanoic acid

SMILES Code:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC) = CC=C4)C=C3)=O

InChi Code:

InChI = 1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H ,32,33)(H,28,29,34)/t16-/m0/s1

InChi Key:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Lo lus tseem ceeb:

2414285-40-6; CAS: 2414285-40-6; CAS: 2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Solubility:Soluble hauv DMSO

Cia:Qhuav, tsaus thiab ntawm 0 - 4 C rau lub sijhawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sijhawm ntev (hli mus rau xyoo)

Nqe lus piav qhia:

Sivopixant, tseem hu ua S-600918, yog xaiv P2X3 receptor antagonist (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). Sivopixant tau pom tias muaj cov nyhuv analgesic nyob rau hauv cov nas ib nrab sciatic paj ligation qauv (Seltzer qauv) ntawm allodynia (ED50, 0.4 mg / kg).

Lub Hom Phiaj: Xaiv P2X3 receptor antagonist