Resmetirom

Lub npe tshuaj:

Resmetirom

SMILES Code:

N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C))=NNC3=O)C(Cl)=C2)C(NC1=O)=O

InChi Code:

InChI = 1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11( 14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27, 28)

InChi Key:

FDBYIYFVSAHJLY-UHFFFAOYSA-N

Lo lus tseem ceeb:

MGL-3196; SIB 3196; VIA 3196; VIA-3196; Resmetirom

Solubility:Soluble hauv DMSO, tsis nyob hauv dej

Cia:0 - 4 C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

Resmetirom, tseem hu ua MGL-3196, yog lub zog thiab xaiv cov thyroid hormone receptor β agonist hauv kev sim tshuaj rau kev kho mob dyslipidemia. Cov txiaj ntsig zoo ntawm cov thyroid hormone (TH) ntawm cov qib lipid feem ntau yog vim nws qhov kev ua ntawm cov thyroid hormone receptor β (THR-β) hauv lub siab, thaum muaj kev cuam tshuam tsis zoo, nrog rau cov teebmeem plawv, yog kho los ntawm cov thyroid hormone receptor α (THR). -a).

Hom phiaj: THR-β